Tumor - Leydig cell; Testicular tumor - Leydig
The cause of this tumor is unknown. There are no known risk factors for this tumor. Unlike germ cell tumors of the testicles, this tumor does not seem to be linked to undescended testes.
Leydig cell tumors make up a very small number of all testicular tumors. They are most often found in men between 30 and 60 years of age. This tumor is not common in children before puberty, but it may cause early puberty.
A physical examination typically reveals a firm lump in one of the testicles. When the health care provider holds a flashlight up to the scrotum, the light does not pass through the lump. This test is called transillumination.
Other tests include:
An examination of the tissue is usually done after the entire testicle is surgically removed (orchiectomy).
Testicular cancer is one of the most treatable and curable cancers. Outlook is worse if the tumor is not found early.
The cancer may spread to other parts of the body. The most common sites include the:
Complications of surgery can include:
If you are of childbearing age, ask your provider about methods to save your sperm for use at a later date.
Performing testicular self-examination (TSE) each month may help detect testicular cancer at an early stage, before it spreads. Finding testicular cancer early is important for successful treatment and survival.
Joining a support group where members share common experiences and problems can often help ease the stress of illness.
There may be no symptoms.
When symptoms do occur, they can include:
Symptoms in other parts of the body, such as the lungs, abdomen, pelvis, back, or brain may also occur if the cancer has spread.
Treatment of a Leydig cell tumor depends on its stage.
Surgery is done to remove the testicle (orchiectomy). Nearby lymph nodes may also be removed (lymphadenectomy).
Chemotherapy may be used to treat this tumor. As Leydig cell tumors are rare, these treatments have not been studied as much as treatments for other, more common testicular cancers.
Call your provider if you have symptoms of testicular cancer.
American Cancer Society website. Signs and symptoms of testicular cancer.
Friedlander TW, Ryan CJ, Small EJ, Torti F. Testicular cancer. In: Niederhuber JE, Armitage JO, Doroshow JH, Kastan MB, Tepper JE, eds. Abeloff's Clinical Oncology. 5th ed. Philadelphia, PA: Elsevier Saunders; 2014:chap 86.
National Cancer Institute website. Testicular cancer treatment (PDQ) - health professional version.
Stephenson AJ, Gilligan TD. Neoplasms of the testis. In: Wein AJ, Kavoussi LR, Partin AW, Peters CA, eds. Campbell-Walsh Urology. 11th ed. Philadelphia, PA: Elsevier; 2016:chap 34.
Review Date: 5/14/2018
Reviewed By: Preeti Sudheendra, MD, oncologist at the MD Anderson Cancer Center at Cooper, Camden, NJ. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.
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