This form of hepatitis is an autoimmune disease. The body's immune system cannot tell the difference between healthy body tissue and harmful, outside substances. The result is an immune response that destroys normal body tissues.
Liver inflammation, or hepatitis, may occur along with other autoimmune diseases. These include:
Autoimmune hepatitis may occur in family members of people with autoimmune diseases. There may be a genetic cause.
This disease is most common in young girls and women.
Autoimmune hepatitis is inflammation of the liver. It occurs when immune cells mistake the liver's normal cells for harmful invaders and attack them.
Tests for autoimmune hepatitis include the following blood tests:
The outcome varies. Corticosteroid medicines may slow the progress of the disease. However, autoimmune hepatitis may advance to cirrhosis. This would require a liver transplant.
Complications may include:
Autoimmune hepatitis cannot be prevented in most cases. Knowing the risk factors may help you detect and treat the disease early.
Symptoms may include:
Absence of menstruation (amenorrhea) may also be a symptom.
You may need prednisone or other corticosteroid medicines to help reduce the inflammation. Azathioprine and 6-mercaptopurine are drugs used to treat other autoimmune disorders. They have been shown to help people with autoimmune hepatitis, as well.
Some people may need a liver transplant.
Call your health care provider if you notice symptoms of autoimmune hepatitis.
Czaja AJ. Autoimmune hepatitis. In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger and Fordtran's Gastrointestinal and Liver Disease. 10th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 90.
Pawlotsky J-M. Chronic viral and autoimmune hepatitis. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 25th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 149.
Review Date: 8/20/2016
Reviewed By: Michael M. Phillips, MD, Clinical Professor of Medicine, The George Washington University School of Medicine, Washington, DC. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.
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